Jared Martin moves next door to the Hansetts, along with his hot motorcycle and eerie, ill-tempered dog. Although everyone else in the neighborhood takes an instant liking to him, Loren Hansett can't get over the bad vibes her new neighbor gives her. She starts to spy on his nocturnal activities and comes to believe that a recent killing might the work of a werewolf who happens to be her new neighbor. Her internet surfing provides a lot of collaborative detail but everyone but her friend Steven dismiss her story as teen-aged fantasy. Fearing for her life, she convinces Steven to take her to a gun shop to buy silver bullets in a gun shop, where their neighbor's supernatural dog attacks. When she dispatches the beast, her actions get the attention of Redd Tucker, a washed-up TV hunting show host to believe her as well. When Steven is attacked by the werewolf and Loren's brother goes missing, she and Redd team up to kill the lycanthrope before he can finish them both off.

In Manhattan, the successful executive Jack is a methodical and controlled man with simple habits that works in an advertisement agency with his coworker George. While smoking a cigarette on the roof of the building of the agency, Jack meets the aspirant actress Jill that has just arrived in New York and is seeking a job. He sympathizes with her situation and gives her name to a Klubendorf commercial in the campaign promoted by his agency. When he takes Jill home, he finds that she lives in a very low-budget hotel and out of the blue, he invites her to stay in the guest room of his fancy apartment for a while. Jill changes the behavior of Jack that becomes happier, and proposes Jack to write together a manifesto where the first rule is "be honest". However, she omits to Jack that she is sick with cystic fibrosis and she would have only a couple of years more. When Jack discovers that Jill is ill...

Kardia weaves fiction and science to tell the story of Hope, a pathologist who embarks on a journey of reconciliation. Hope discovers that the experimental heart operation she underwent as a child has mysteriously linked her life with another. To unlock the secret of her past, Hope must revisit her childhood and explore regions of her life that have heart stopping results.

The Special Investigation Squad, an elite secret police force, hunts down criminals in the streets of Los Angeles.